Rr132em1Abfi
Endonuclease-mediated Allele Detail
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Symbol: |
Rr132em1Abfi |
Name: |
regulatory region 132; endonuclease-mediated mutation 1, Anthony B Firulli |
MGI ID: |
MGI:6476937 |
Synonyms: |
Hand1deltaLV, Hand1em1Abfi |
Gene: |
Rr132 Location: unknown Genetic Position: Chr11, Syntenic
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Alliance: |
Rr132em1Abfi page
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Allele Type: |
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Endonuclease-mediated (Modified regulatory region) |
Mutation: |
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Intragenic deletion
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Mutation details: CRISPR-targeting removed the left ventricle (LV) enhancer located upstream of the Hand1 gene transcription initiation site (744 bp located at chr11:57660605-57661348; NCBIm37/mm9). This allele contains a 750 bp deletion encompassing all but 4 bp on the 5' end of the enhancer.
(J:294964)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rr132 Mutation: |
0 strains or lines available
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Original: |
J:294964 Vincentz JW, et al., Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function. Circ Res. 2019 Aug 30;125(6):575-589 |
All: |
1 reference(s) |
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