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Hand1
Gene Detail
Symbol

Name
ID
Hand1
heart and neural crest derivatives expressed transcript 1
MGI:103577
Synonyms
bHLHa27, eHAND, Ehand1, Hxt, Th1, Thing1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
35.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:57828707-57832818 bp, - strand
From VEGA annotation of GRCm38

  4112 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3545  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog

Gene Tree: Hand1

Human
homologs
Human Homolog HAND1, heart and neural crest derivatives expressed 1
NCBI Gene ID 9421
neXtProt AC  NX_O96004
Human Synonyms  bHLHa27, eHand, Hxt, Thing1
Human Chr (Location)  5q33; chr5:154474972-154478264 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations die at embryonic day 8.5-9.5 with yolk sac abnormalities associated with a deficiency of extraembryonic mesoderm and defective trophoblast differentiation. Tetraploid chimeric rescue slightly extends development.
 
Interactions
Hand1 interacts with 131 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (63 annotations)
Process angiogenesis, cardiac left ventricle formation, ...
Component cytoplasm, nucleolus, ...
Function bHLH transcription factor binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (178 records)
Data Summary: Results (664)    Tissues (408)    Images (179)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 477
In situ reporter (knock in) 57
Northern blot 43
RT-PCR 81
RNase protection 5
cDNA source data(78)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(110) Genomic(2) cDNA(84) Primer pair(12) Other(12)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000005713 (Evidence)
Ensembl Gene ModelENSMUSG00000037335 (Evidence)
Entrez Gene15110 (Evidence)
UniGene4746
DFCITC1580194
DoTSDT.101238751, DT.482406
NIA Mouse Gene IndexU032799
Consensus CDS ProjectCCDS24721.1
International Mouse Knockout Project StatusHand1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005713 VEGA Gene Model | MGI Sequence Detail 4112 C57BL/6J ±  kb
transcript OTTMUST00000012705 VEGA | MGI Sequence Detail 1904 Not Applicable 
polypeptide OTTMUSP00000005886 VEGA | MGI Sequence Detail 216 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000008439 heart- and neural crest derivatives-expressed protein 1
References
(Earliest) J:22312 Oude Elferink RP, et al., Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse. J Clin Invest. 1995 Jan;95(1):31-8
(Latest) J:210349 Mainigi MA, et al., Peri-implantation hormonal milieu: elucidating mechanisms of abnormal placentation and fetal growth. Biol Reprod. 2014 Feb;90(2):26
All references(214)
Other
accession IDs
MGD-MRK-24462, MGD-MRK-25634, MGI:104306

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory