Nfatc2^tm1.1Ecan
Targeted Allele Detail

Summary

• Symbol: Nfatc2^tm1.1Ecan
• Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2; targeted mutation 1.1, Ernesto Canalis
• MGI ID: MGI:6469915
• Synonyms: Nfatc2^loxP
• Gene: Nfatc2 Location: Chr2:168318330-168443577 bp, - strand Genetic Position: Chr2, 88.91 cM
• Alliance: Nfatc2^tm1.1Ecan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:289229
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129X1/SvJ x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A 5' loxP site was introduced approximately 0.4 kb 5' of exon 2, followed by the insertion of a FRT-flanked PGK promoter-driven neomycin selection cassette, and a 3' loxP site approximately 0.4 kb 3' of exon 2. Flp-mediated recombination removed the selection cassette leaving exon 2 floxed. (J:289229)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nfatc2 Mutation: 55 strains or lines available

References

• Original: J:289229 Yu J, et al., Nuclear factor of activated T cells 2 is required for osteoclast differentiation and function in vitro but not in vivo. J Cell Biochem. 2018 Nov;119(11):9334-9345
• All: 2 reference(s)