S1pr2^tm1.1Thla
Targeted Allele Detail

Summary

• Symbol: S1pr2^tm1.1Thla
• Name: sphingosine-1-phosphate receptor 2; targeted mutation 1.1, Timothy Hla
• MGI ID: MGI:6468214
• Synonyms: S1pr2^-
• Gene: S1pr2 Location: Chr9:20877248-20888089 bp, - strand Genetic Position: Chr9, 7.68 cM
• Alliance: S1pr2^tm1.1Thla page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287983
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site into the 5' UTR, upstream of the first coding exon (exon 2). A second loxP site is inserted downstream of the 3' UTR, followed by a cassette containing an FRT-flanked PGK-neo and a third loxP site. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 2 floxed. (J:287983)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any S1pr2 Mutation: 45 strains or lines available

References

• Original: J:287983 Cartier A, et al., Endothelial sphingosine 1-phosphate receptors promote vascular normalization and antitumor therapy. Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):3157-3166
• All: 2 reference(s)