Ticrr^em1(IMPC)Bay
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ticrr^em1(IMPC)Bay
• Name: TOPBP1-interacting checkpoint and replication regulator; endonuclease-mediated mutation 1, Baylor College of Medicine
• MGI ID: MGI:6467486
• Synonyms: Ticrr^-
• Gene: Ticrr Location: Chr7:79309944-79347896 bp, + strand Genetic Position: Chr7, 45.09 cM, cytoband D2
• Alliance: Ticrr^em1(IMPC)Bay page
• IMPC: Ticrr gene page

Ticrr^em1(IMPC)Bay/Ticrr^em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 as morulae but not at E7.5. Embryos fail to hatch from the zona pellucida and die after 3 days in culture, never forming outgrowths.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6N
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at Baylor College of Medicine using Cas9 and guides with spacer sequences ATAGAAGCTATCGGCCGTTT and GGATTTAGCCGGCTCACATC that targeted exon(s) ENSMUSE00000592187.2. This resulted in deletion(s) of 886 bp (location: Chr7:79318681-79319566; GRCm39). This description was generated automatically. Additional molecular information including FASTA sequence support for this allele can be found here: (IMPC Gene page) and viewed in a genome context here: (IMPC Genome Browser). (J:384794)

• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ticrr Mutation: 78 strains or lines available

References

• Original: J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023
• All: 5 reference(s)