Gm12250^em1Tdk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gm12250^em1Tdk
• Name: predicted gene 12250; endonuclease-mediated mutation 1, Thirumala-Devi Kanneganti
• MGI ID: MGI:6466631
• Synonyms: IRGB10^-
• Gene: Gm12250 Location: Chr11:58074669-58081024 bp, + strand Genetic Position: Chr11, 35.96 cM
• Alliance: Gm12250^em1Tdk page

Mutation origin

• Strain of Origin: (C57BL/6 x C3H)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRIPSR/Cas9 genome editing technology was used to generate a deletion in the gene. Details not specified. (J:236523)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gm12250 Mutation: 6 strains or lines available

References

• Original: J:236523 Man SM, et al., IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes. Cell. 2016 Oct 6;167(2):382-396.e17
• All: 6 reference(s)