Tpte^tm1Osb
Targeted Allele Detail

Summary

• Symbol: Tpte^tm1Osb
• Name: transmembrane phosphatase with tensin homology; targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6458829
• Gene: Tpte Location: Chr8:22773457-22861432 bp, + strand Genetic Position: Chr8, 11.2 cM
• Alliance: Tpte^tm1Osb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282803
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct introduced into exon 21 a Venus reporter gene, polyadenylation sequence, and floxed neomycin resistance cassette. The modified allele lacks the 3 end of the phosphatase domain and all of the C2 domain. (J:282803)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tpte Mutation: 39 strains or lines available

References

• Original: J:282803 Kawai T, et al., Polarized PtdIns(4,5)P2 distribution mediated by a voltage-sensing phosphatase (VSP) regulates sperm motility. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):26020-26028
• All: 2 reference(s)