Serinc3^{tm1b(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Serinc3^{tm1b(KOMP)Wtsi}
• Name: serine incorporator 3; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:6456580
• Gene: Serinc3 Location: Chr2:163466577-163487767 bp, - strand Genetic Position: Chr2, 84.38 cM
• Alliance: Serinc3^{tm1b(KOMP)Wtsi} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:291232
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated excision of the parental Serinc5^{tm1a(KOMP)Wtsi} allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exon 3 leaving behind the inserted lacZ reporter sequence. RT-qPCR shows significantly lower mRNA transcript levels in homozygotes. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:291232)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Serinc3 Mutation: 45 strains or lines available

References

• Original: J:291232 Timilsina U, et al., SERINC5 Potently Restricts Retrovirus Infection In Vivo. mBio. 2020 Jul 14;11(4)
• All: 1 reference(s)