Per2^em2Vrshp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Per2^em2Vrshp
• Name: period circadian clock 2; endonuclease-mediated mutation 2, David Virshup
• MGI ID: MGI:6453861
• Synonyms: Per2^S478A
• Gene: Per2 Location: Chr1:91343704-91387046 bp, - strand Genetic Position: Chr1, 46.13 cM, cytoband C5
• Alliance: Per2^em2Vrshp page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 genome editing was used to insert TCC AGT to TCA GCT mutations in codons 477 and 478, resulting in the insertion of a serine to alanine point mutation in codon 478 (S478A). (J:288606)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Per2 Mutation: 71 strains or lines available

References

• Original: J:288606 Masuda S, et al., Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch. Proc Natl Acad Sci U S A. 2020 May 19;117(20):10888-10896
• All: 1 reference(s)