Zfp708^em1Dame
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zfp708^em1Dame
• Name: zinc finger protein 708; endonuclease-mediated mutation 1, Daniel M Messerschmidt
• MGI ID: MGI:6444753
• Synonyms: Zfp708^-
• Gene: Zfp708 Location: Chr13:67217463-67246040 bp, - strand Genetic Position: Chr13, 34.54 cM
• Alliance: Zfp708^em1Dame page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A 4 bp deletion was created in the KRAB-A domain using gRNAs and cRNA with CRISPR/Cas9 technology. The resulting truncated peptide, if produced, would lack KRAB domains and zinc fingers. (J:284126)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp708 Mutation: 27 strains or lines available

References

• Original: J:284126 Seah MKY, et al., The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons. Development. 2019 Jul 10;146(19):dev170266
• All: 1 reference(s)