Tg(IgK-JV-KL25)1Dpin
Transgene Detail

Summary

• Symbol: Tg(IgK-JV-KL25)1Dpin
• Name: transgene insertion 1, Daniel Pinschewer
• MGI ID: MGI:6429850
• Synonyms: Tg(KL25L)Tac
• Transgene: Tg(IgK-JV-KL25)1Dpin Location: unknown
• Alliance: Tg(IgK-JV-KL25)1Dpin page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(IgK-JV-KL25)1Dpin expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Igk (MGI:96494)	expresses a rearranged Igk chain from KL25 clone

• Mutation details: This transgene uses a genomic immunoglobulin kappa (Ig) chain promoter to drive expression of rearranged V and J segments from the KL25 clone, including leader and intronfollowed by a light chain kappa constant domain, and IRES followed by a cell surface reporter protein consisting of the murine Thy1.1 ectodomain fused to the transmembrane and cytoplasmic domains of the mouse PDGF receptor. (J:259174)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:259174 Fallet B, et al., Interferon-driven deletion of antiviral B cells at the onset of chronic infection. Sci Immunol. 2016 Oct 21;1(4)
• All: 2 reference(s)