Malt1^{tm1b(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Malt1^{tm1b(EUCOMM)Hmgu}
• Name: MALT1 paracaspase; targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:6415664
• Synonyms: Malt1^IRES-LacZ
• Gene: Malt1 Location: Chr18:65564010-65612138 bp, + strand Genetic Position: Chr18, 38.56 cM
• Alliance: Malt1^{tm1b(EUCOMM)Hmgu} page
• IMPC: Malt1 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:280708
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 65577475 of Chromosome 18 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 65578310. The critical exon(s) is/are thus flanked by loxP sites. If cre expression occurs without flp expression, a reporter knockout mouse will be created. A null/knockout allele was created by cre recombinase expression in mice carrying the tm1a allele to remove the neo selection cassette and loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:280708)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Malt1 Mutation: 33 strains or lines available

References

• Original: J:280708 Demeyer A, et al., MALT1-Deficient Mice Develop Atopic-Like Dermatitis Upon Aging. Front Immunol. 2019;10:2330
• All: 2 reference(s)