Plekha5^em1(IMPC)Tcp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Plekha5^em1(IMPC)Tcp
• Name: pleckstrin homology domain containing, family A member 5; endonuclease-mediated mutation 1, The Centre for Phenogenomics
• MGI ID: MGI:6414535
• Gene: Plekha5 Location: Chr6:140369780-140542836 bp, + strand Genetic Position: Chr6, 70.34 cM
• Alliance: Plekha5^em1(IMPC)Tcp page
• IMPC: Plekha5 gene page

Mutation origin

• Strain of Origin: C57BL/6NCrl
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele from project TCPR1560 was generated at The Centre for Phenogenomics by electroporating Cas9 ribonucleoprotein complexes with single guide RNAs having spacer sequences of TACAGTTCTCGGGCCGTAGA targeting the 5' side and TTAGGAAGCACGTACTAGCA targeting the 3' side of a critical region. This resulted in a 858-bp deletion Chr6:140534052-140534909 (GRCm38). (J:265051)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Plekha5 Mutation: 109 strains or lines available

References

• Original: J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023
• All: 2 reference(s)