Gt(ROSA)26Sor^{tm3041.1(CAG-Malat1)Arte}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm3041.1(CAG-Malat1)Arte}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3041.1, TaconicArtemis
• MGI ID: MGI:6403289
• Synonyms: Malat1^Tg
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm3041.1(CAG-Malat1)Arte} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268398
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm3041.1(CAG-Malat1)Arte} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Malat1 (MGI:1919539)

• Mutation details: RMCE inserted into the locus a splice-acceptor, F3 site, neomycin resistance gene, general polyadenylation sequence, CAG promoter, floxed stop cassette, Malat1, human growth hormone polyadenylation sequence, general polyadenylation sequence, and FRT site. Cre-mediated recombination removed the STOP cassette. (J:268398)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1060 strains or lines available

Notes

ES cells = Art B6 RMCE 101.2 (genetic background C57BL/6NTac)

References

• Original: J:268398 Kim J, et al., Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nat Genet. 2018 Dec;50(12):1705-1715
• All: 4 reference(s)