Ifngr2^tm1.1Lflu
Targeted Allele Detail

Summary

• Symbol: Ifngr2^tm1.1Lflu
• Name: interferon gamma receptor 2; targeted mutation 1.1, Li-fan Lu
• MGI ID: MGI:6402706
• Synonyms: Ifngammar2^fl
• Gene: Ifngr2 Location: Chr16:91343947-91360895 bp, + strand Genetic Position: Chr16, 53.07 cM
• Alliance: Ifngr2^tm1.1Lflu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241424
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: (C57BL/6 x 129S1/SvImJ)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the selection cassette and left exons 5 and 6 floxed. (J:241424)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ifngr2 Mutation: 24 strains or lines available

Notes

ES cell= IDF32F1 (C57BL/6 x 129S1/SvImJ)F1

References

• Original: J:241424 Lee HM, et al., IFNgamma signaling endows DCs with the capacity to control type I inflammation during parasitic infection through promoting T-bet+ regulatory T cells. PLoS Pathog. 2015 Feb;11(2):e1004635
• All: 11 reference(s)