Tg(Hdnr-icre)betaPhg
Transgene Detail

Summary

• Symbol: Tg(Hdnr-icre)betaPhg
• Name: transgene insertion beta, Phillip Grote
• MGI ID: MGI:6400491
• Synonyms: Tg(5033428I22Rik-icre)betaPhg, tg(RP23-353N18,TSS^HdnbetaiCre)Phg
• Transgene: Tg(Hdnr-icre)betaPhg Location: unknown
• Alliance: Tg(Hdnr-icre)betaPhg page

Transgene origin

• Mouse Generated: Earliest citation of chimera generation: J:284123
• Parent Cell Line: F1H4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Hdnr-icre)betaPhg expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hdnr (MGI:1923246)

• Mutation details: The transgene was made using BAC RP23-353N18 with the improves cre recombinase gene inserted downstream of the Hdnr beta isoform transcriptional start site. The transgene was inserted into a ROSA26R-lacZ reporter harboring mouse embryonic stem cell lines (mESCs). From these mESCs, embryos were generated by tetraploid morula aggregation and analyzed in three embryos derived. (J:284123)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hdnr (mouse) Summary of all recombinase alleles driven by Hdnr. Comparative matrix view of recombinase activities Alliance mouse Hdnr gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:284123 Ritter N, et al., The lncRNA Locus Handsdown Regulates Cardiac Gene Programs and Is Essential for Early Mouse Development. Dev Cell. 2019 Sep 9;50(5):644-657.e8
• All: 1 reference(s)