Ndfip2^tm1.1Pmo
Targeted Allele Detail

Summary

• Symbol: Ndfip2^tm1.1Pmo
• Name: Nedd4 family interacting protein 2; targeted mutation 1.1, Paula M Oliver
• MGI ID: MGI:6392820
• Gene: Ndfip2 Location: Chr14:105496008-105546732 bp, + strand Genetic Position: Chr14, 55.64 cM
• Alliance: Ndfip2^tm1.1Pmo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236888
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector containing an EGFP reporter followed by polyadenylation signal and an F3-flanked puromycin resistance cassette was inserted into exon 2, resulting in a partial deletion of exon 2 and deletion of exons 3 and 4. Flp-mediated recombination removed the FRT-flanked puro cassette. (J:236888)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ndfip2 Mutation: 28 strains or lines available

References

• Original: J:236888 O'Leary CE, et al., Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells. Nat Commun. 2016 Apr 18;7:11226
• All: 2 reference(s)