Lypd4^tm1Osb
Targeted Allele Detail

Summary

• Symbol: Lypd4^tm1Osb
• Name: Ly6/Plaur domain containing 4; targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:6387029
• Gene: Lypd4 Location: Chr7:24564044-24569180 bp, - strand Genetic Position: Chr7, 13.3 cM
• Alliance: Lypd4^tm1Osb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279308
• Parent Cell Line: EGR-G01 (ES Cell)
• Strain of Origin: (129S2/SvPas x C57BL/6NSlc)F1-Tg(CAG-EGFP,Acr-EGFP)2Osb

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4-5 were replaced with a loxP site and FRT-flanked neomycin cassette. Western blot analysis confirmed absence of protein in testicular germ cell lysates. (J:279308)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Lypd4 Mutation: 19 strains or lines available

References

• Original: J:279308 Fujihara Y, et al., Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18498-18506
• All: 1 reference(s)