Gt(ROSA)26Sor^{tm1(CAG-Dnd1)Matn}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Dnd1)Matn}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Angabin Matin
• MGI ID: MGI:6386785
• Synonyms: LSL-FM-DND1^flox
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Dnd1)Matn} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:281756
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-Dnd1)Matn} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Dnd1 (MGI:2447763)

• Mutation details: The targeting construct inserted into the locus a CAGGS promoter (CAG), a floxed PGK-puromycin STOP cassette (LSL), the mouse Dnd1 cDNA with N-terminal FLAG and myc tags, and an frt site. Upon cre-mediated excision of the STOP cassette, the minigene constitutively expresses the FLAG/myc tagged Dnd1 driven by the CAG promoter. (J:281756)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1095 strains or lines available

References

• Original: J:281756 Nunez L, et al., Generation of a novel mouse strain with conditional, cell-type specific, expression of DND1. Genesis. 2019 Nov;57(11-12):e23335
• All: 1 reference(s)