Mertk^em1Doi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mertk^em1Doi
• Name: MER proto-oncogene tyrosine kinase; endonuclease-mediated mutation 1, Christophe Benoist and Diane Mathis
• MGI ID: MGI:6386251
• Synonyms: Mertk^GFPiDTR
• Gene: Mertk Location: Chr2:128540876-128644814 bp, + strand Genetic Position: Chr2, 62.63 cM
• Alliance: Mertk^em1Doi page

Mutation origin

• Strain of Origin: NOD

Mutation description

• Allele Type: Endonuclease-mediated (Epitope tag, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing is used to introduce a 5' HA tag, an EGFP reporter, an IRES, and a DTR with an SV40 polyadenylation sequence and 3' HA tag into exon 1, following the ATG codon. The insertion results in a 53 bp deletion in the remainder of exon 1. (J:253628)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mertk Mutation: 66 strains or lines available

References

• Original: J:253628 Mohan JF, et al., Imaging the emergence and natural progression of spontaneous autoimmune diabetes. Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7776-E7785
• All: 1 reference(s)