Hand2os1^em1Tshu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hand2os1^em1Tshu
• Name: Hand2, opposite strand 1; endonuclease-mediated mutation 1, Tsinghua University
• MGI ID: MGI:6383823
• Synonyms: Hand2os1^P
• Gene: Hand2os1 Location: Chr8:57757296-57773894 bp, - strand Genetic Position: Chr8, Syntenic
• Alliance: Hand2os1^em1Tshu page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Hypomorph)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting removed 1 kb of the the core promoter and first 2 exons. The deletion starts at -61 bp and -62bp upstream of transcription start site of Hand2os1 and Hand2. (J:278239)

Expression

In Mice Carrying this Mutation:

10 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hand2os1 Mutation: 0 strains or lines available

References

• Original: J:278239 Han X, et al., The lncRNA Hand2os1/Uph locus orchestrates heart development through regulation of precise expression of Hand2. Development. 2019 Jul 4;146(13):dev176198
• All: 1 reference(s)