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Hand2os1em1Tshu
Endonuclease-mediated Allele Detail
Summary
Symbol: Hand2os1em1Tshu
Name: Hand2, opposite strand 1; endonuclease-mediated mutation 1, Tsinghua University
MGI ID: MGI:6383823
Synonyms: Hand2os1P
Gene: Hand2os1  Location: Chr8:57757296-57773894 bp, - strand  Genetic Position: Chr8, Syntenic
Alliance: Hand2os1em1Tshu page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Hypomorph)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR-targeting removed 1 kb of the the core promoter and first 2 exons. The deletion starts at -61 bp and -62bp upstream of transcription start site of Hand2os1 and Hand2. (J:278239)
Expression
In Mice Carrying this Mutation: 10 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hand2os1 Mutation:  0 strains or lines available
References
Original:  J:278239 Han X, et al., The lncRNA Hand2os1/Uph locus orchestrates heart development through regulation of precise expression of Hand2. Development. 2019 Jul 4;146(13):dev176198
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory