Prmt5^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Prmt5^{tm1c(EUCOMM)Wtsi}
• Name: protein arginine N-methyltransferase 5; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:6378991
• Synonyms: Prmt5^l, Prmt5^loxP
• Gene: Prmt5 Location: Chr14:54744639-54754927 bp, - strand Genetic Position: Chr14, 27.82 cM, cytoband C1
• Alliance: Prmt5^{tm1c(EUCOMM)Wtsi} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:281518
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT-lacZ-loxP-hACTB promoter-neomycin-FRT-loxP cassette was introduced to intron 6 and a loxP site was placed in intron 7. Flp-mediated recombination removed the FRT-flanked lacZ/neo cassette leaving exon 7 floxed. (J:281518)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prmt5 Mutation: 44 strains or lines available

References

• Original: J:281518 Ma J, et al., Islet-specific Prmt5 excision leads to reduced insulin expression and glucose intolerance in mice. J Endocrinol. 2020 Jan 1;244(1):41-52
• All: 1 reference(s)