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Rr27tm1.1Keij
Targeted Allele Detail
Summary
Symbol: Rr27tm1.1Keij
Name: regulatory region 27; targeted mutation 1.1, Keiji Tanimoto
MGI ID: MGI:6368127
Synonyms: 5'ICR-KO
Gene: Rr27  Location: Chr7:142133885-142136283 bp  Genetic Position: Chr7, Syntenic
Alliance: Rr27tm1.1Keij page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:226694
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Modified regulatory region)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site flanked neomycin resistance gene cassette was inserted upstream of the H19 ICR. An additional loxP site was inserted downstream of the ICR. Cre-mediated recombination removed the selection cassette and ICR. (J:226694)
Expression
In Mice Carrying this Mutation: 48 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr27 Mutation:  7 strains or lines available
References
Original:  J:226694 Matsuzaki H, et al., De novo DNA methylation through the 5'-segment of the H19 ICR maintains its imprint during early embryogenesis. Development. 2015 Nov 15;142(22):3833-44
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory