Pam^tm1.1Npl
Targeted Allele Detail

Summary

• Symbol: Pam^tm1.1Npl
• Name: peptidylglycine alpha-amidating monooxygenase; targeted mutation 1.1, Neuropeptide Laboratory
• MGI ID: MGI:6360953
• Synonyms: PAM^cKO
• Gene: Pam Location: Chr1:97748816-98023578 bp, - strand Genetic Position: Chr1, 47.76 cM
• Alliance: Pam^tm1.1Npl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278986
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 2 and a rox-flanked neomycin selection (neo) cassette downstream of exon 3, followed by a second loxP site. Dre-mediated recombination removed the rox-flanked neo cassette leaving exons 2-3 floxed. (J:278986)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pam Mutation: 62 strains or lines available

References

• Original: J:278986 Powers KG, et al., Identifying roles for peptidergic signaling in mice. Proc Natl Acad Sci U S A. 2019 Aug 27
• All: 2 reference(s)