Ifngas1^em1Oshea
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ifngas1^em1Oshea
• Name: Ifng antisense RNA 1; endonuclease-mediated mutation 1, John O'Shea
• MGI ID: MGI:6359822
• Synonyms: Ifng-as1 PolyA KI
• Gene: Ifngas1 Location: Chr10:118337940-118392430 bp, - strand Genetic Position: Chr10, Syntenic
• Alliance: Ifngas1^em1Oshea page

Mutation origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 genome editing is used to insert a bovine growth hormone cassette and a poly adenylation sequence 70 base pairs after the transcription start site. The mutation results in premature termination of Ifngas1 transcription without disrupting the local chromatin architecture. (J:283672)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ifngas1 Mutation: 1 strain or line available

References

• Original: J:283672 Petermann F, et al., The Magnitude of IFN-gamma Responses Is Fine-Tuned by DNA Architecture and the Non-coding Transcript of Ifng-as1. Mol Cell. 2019 Sep 19;75(6):1229-1242.e5
• All: 1 reference(s)