Sftpc^{tm1(dre/ERT2)Bzsh}
Targeted Allele Detail

Summary

• Symbol: Sftpc^{tm1(dre/ERT2)Bzsh}
• Name: surfactant associated protein C; targeted mutation 1, Bin Zhou
• MGI ID: MGI:6357171
• Synonyms: Sftpc-DreER
• Gene: Sftpc Location: Chr14:70758389-70761521 bp, - strand Genetic Position: Chr14, 36.32 cM
• Alliance: Sftpc^{tm1(dre/ERT2)Bzsh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278107
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Sftpc^{tm1(dre/ERT2)Bzsh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sftpc (MGI:109517)

• Mutation details: A targeting vector containing DreER cDNA, SV40 poly(A) sequence and Frt site-flanked PGK-EM7-Neo resistance gene was used to insert a cDNA encoding Dre recombinase fused with a mutant form of the estrogen-receptor hormone-binding domain in frame with the translational start codon (ATG) of the Sftpc gene. (J:278107)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sftpc (mouse) Summary of all recombinase alleles driven by Sftpc. Comparative matrix view of recombinase activities Alliance mouse Sftpc gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sftpc Mutation: 23 strains or lines available

References

• Original: J:278107 Liu Q, et al., Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction. Nat Genet. 2019 Apr;51(4):728-738
• All: 3 reference(s)