Vim^tm1Sibg
Targeted Allele Detail

Summary

• Symbol: Vim^tm1Sibg
• Name: vimentin; targeted mutation 1, Shigeyoshi Itohara
• MGI ID: MGI:6355955
• Synonyms: Vim^SA
• Gene: Vim Location: Chr2:13579122-13587637 bp, + strand Genetic Position: Chr2, 10.04 cM, cytoband A2
• Alliance: Vim^tm1Sibg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276637
• Parent Cell Line: EB3 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details:

  Targeted mutagenesis was used to generate mutations resulting in the substitution of select serine residues to alanine in the vimentin head domain of the encoded protein. These include codons 7, 25, 39, 47, 56, 65, 66, 72, 73, 83, and 87 in exon 1. In the encoded protein, the mutation changes a phosphorylatable residue into one that cannot be phosphorylated. (J:276637)

Expression

In Mice Carrying this Mutation:	53 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vim Mutation: 40 strains or lines available

References

• Original: J:276637 Matsuyama M, et al., Defect of mitotic vimentin phosphorylation causes microophthalmia and cataract via aneuploidy and senescence in lens epithelial cells. J Biol Chem. 2013 Dec 13;288(50):35626-35
• All: 2 reference(s)