Mettl14^em1Flv
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mettl14^em1Flv
• Name: methyltransferase 14, N6-adenosine-methyltransferase subunit; endonuclease-mediated mutation 1, Richard Flavell
• MGI ID: MGI:6343526
• Synonyms: Mettl14^Lox
• Gene: Mettl14 Location: Chr3:123161944-123179639 bp, - strand Genetic Position: Chr3, 53.96 cM
• Alliance: Mettl14^em1Flv page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• LoxP sites were inserted into the first and last introns using CRISPR/cas9 mutagenesis. (J:249262)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mettl14 Mutation: 37 strains or lines available

References

• Original: J:249262 Li HB, et al., m(6)A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways. Nature. 2017 Aug 17;548(7667):338-342
• All: 4 reference(s)