Mettl23^em1Ogu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mettl23^em1Ogu
• Name: methyltransferase like 23; endonuclease-mediated mutation 1, Atsuo Ogura
• MGI ID: MGI:6342883
• Synonyms: Mettl23-KO
• Gene: Mettl23 Location: Chr11:116734341-116740566 bp, + strand Genetic Position: Chr11, 81.49 cM, cytoband E2
• Alliance: Mettl23^em1Ogu page

Mutation origin

• Strain of Origin: B6D2F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: An 11 bp deletion was generated by CRISPR/Cas9 mutagenesis. Western blot analysis confirmed the absence of protein expression in the testes of adult homozygous male mice. (J:254851)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mettl23 Mutation: 20 strains or lines available

References

• Original: J:254851 Hatanaka Y, et al., Histone H3 Methylated at Arginine 17 Is Essential for Reprogramming the Paternal Genome in Zygotes. Cell Rep. 2017 Sep 19;20(12):2756-2765
• All: 1 reference(s)