Fbxw15^{em1(IMPC)Ccpcz}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fbxw15^{em1(IMPC)Ccpcz}
• Name: F-box and WD-40 domain protein 15; endonuclease-mediated mutation 1, Institute of Molecular Genetics
• MGI ID: MGI:6341864
• Gene: Fbxw15 Location: Chr9:109381670-109397330 bp, - strand Genetic Position: Chr9, 59.67 cM
• Alliance: Fbxw15^{em1(IMPC)Ccpcz} page
• IMPC: Fbxw15 gene page

Mutation origin

• Strain of Origin: C57BL/6NCrl
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at Czech Centre for Phenogenomics using Cas9 and guides with spacer sequences GTAATCCATTAATCATTTGG and TATATTGTTCTCCTACAAGG that targeted exon(s) ENSMUSE00001043656.2 ENSMUSE00001052342.2 ENSMUSE00000978621.2 ENSMUSE00000990464.2 ENSMUSE00001024125.2 ENSMUSE00001025660.2 ENSMUSE00001055344.2 ENSMUSE00001069815.2 ENSMUSE00001089417.2 ENSMUSE00001094671.2 ENSMUSE00001351583.2 ENSMUSE00001354288.2 ENSMUSE00001355307.2 ENSMUSE00001628087.1 ENSMUSE00001628088.1 ENSMUSE00001628089.1 ENSMUSE00001628090.1. This resulted in deletion(s) of 4 bp (location: Chr9:109453105-109453108; GRCm39), 8 bp (location: Chr9:109453123-109453130; GRCm39), 12 bp (location: Chr9:109453142-109453153; GRCm39), 98 bp (location: Chr9:109453173-109453270; GRCm39), 951 bp (location: Chr9:109452138-109453088; GRCm39), 1001 bp (location: Chr9:109393966-109394966; GRCm39), and 56699 bp (location: Chr9:109395416-109452114; GRCm39). This description was generated automatically. Additional molecular information including FASTA sequence support for this allele can be found here: (IMPC Gene page) and viewed in a genome context here: (IMPC Genome Browser). (J:384794)

• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fbxw15 Mutation: 39 strains or lines available

References

• Original: J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023
• All: 4 reference(s)