Rr152^tm9.1Cog
Targeted Allele Detail

Summary

• Symbol: Rr152^tm9.1Cog
• Name: regulatory region 152; targeted mutation 9.1 Michel Cogne
• MGI ID: MGI:6317346
• Synonyms: deltaIRIS, Igh^tm9.1Cog
• Gene: Rr152 Location: Chr12:113191890-113217660 bp Genetic Position: Chr12, Syntenic
• Alliance: Rr152^tm9.1Cog page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234741
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutation: Intergenic deletion
• Mutation details: The Igh 3' regulatory region (3'RR) controls class switch recombination (CSR) and somatic hypermutation (SHM) in B cells. The mouse 3'RR contains four enhancer elements with hs1,2 (Rr153) flanked by inverted repeated intervening sequences (IRIS) and the center of a 25-kb palindrome bounded by two hs3 enhancer inverted copies (hs3a (Rr154) and hs3b (Rr155)). Enhancer hs4 (Rr156) lies downstream of the palindrome. This allele fully eliminates the left-side IRIS while maintaining all four core enhancer elements. (J:234741)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rr152 Mutation: 6 strains or lines available

References

• Original: J:234741 Saintamand A, et al., Deciphering the importance of the palindromic architecture of the immunoglobulin heavy-chain 3' regulatory region. Nat Commun. 2016;7:10730
• All: 2 reference(s)