Ctla4^{tm1.1(CTLA4)Geno}
Targeted Allele Detail

Summary

• Symbol: Ctla4^{tm1.1(CTLA4)Geno}
• Name: cytotoxic T-lymphocyte-associated protein 4; targeted mutation 1.1, Genoway
• MGI ID: MGI:6315564
• Synonyms: Ctla4^{tm1.1(hCTLA4)Geno}, Ctla4^{tm1(huCTLA4-ICP13)Geno}
• Gene: Ctla4 Location: Chr1:60948184-60954991 bp, + strand Genetic Position: Chr1, 30.58 cM, cytoband C
• Alliance: Ctla4^{tm1.1(CTLA4)Geno} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276209
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The chimaeric allele expresses the full length chimeric CTLA-4 isoform (human extracellular domain and mouse intracellular domain) and the soluble isoform (human extracellular domain). Flp-mediated recombination removed the selection cassette. (J:276209)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ctla4 Mutation: 49 strains or lines available

Notes

https://www.genoway.com/services/catalog/humanized-mouse/immune-checkpoints.htm

References

• Original: J:276209 Sonego F, Direct Data Submission for Genoway Humanized Immune Checkpoint (ICP) Mice. MGI Direct Data Submission. 2019
• All: 2 reference(s)