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Naa10tm1.1Yzhg
Targeted Allele Detail
Summary
Symbol: Naa10tm1.1Yzhg
Name: N(alpha)-acetyltransferase 10, NatA catalytic subunit; targeted mutation 1.1, Yi Zhang
MGI ID: MGI:6315272
Synonyms: Naa10-
Gene: Naa10  Location: ChrX:72960479-72965550 bp, - strand  Genetic Position: ChrX, 37.49 cM
Alliance: Naa10tm1.1Yzhg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:251884
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted into intron 1 and an frt-flanked neomycin selection cassette followed by second loxP site were inserted into intron 6. Exons 2 to 6 and the neo cassette were thus flanked by loxP sites. Cre mediated recombination resulted in the deletion of exons 2-6 and the neomycin selection cassette. Western blot analysis demonstrated that the encoded protein is undetectable in mouse embryonic fibroblasts derived from hemizygous male mice. (J:251884)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Naa10 Mutation:  10 strains or lines available
References
Original:  J:251884 Lee CC, et al., The Role of N-alpha-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting. Mol Cell. 2017 Oct 5;68(1):89-103.e7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory