Tdo2tm1.1Dkfz
Targeted Allele Detail
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Symbol: |
Tdo2tm1.1Dkfz |
Name: |
tryptophan 2,3-dioxygenase; targeted mutation 1.1, German Cancer Research Center |
MGI ID: |
MGI:6306653 |
Synonyms: |
reporter-TDO, Tdo2tm#(GFP/Luc)/Dkfz |
Gene: |
Tdo2 Location: Chr3:81865719-81883035 bp, - strand Genetic Position: Chr3, 35.97 cM
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Alliance: |
Tdo2tm1.1Dkfz page
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Germline Transmission: |
Earliest citation of germline transmission:
J:275089
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Parent Cell Line: |
JM8A1.N3 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutation: |
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Insertion
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Mutation details: A copGFP and a firefly luciferase gene were inserted into the gene, starting at the start codon. An frt-flanked neomycin selection cassette was inserted following the reporter genes. A stop codon was inserted at the 5' end of the inserted construct. The neomycin selection cassette was remove via FLP-mediated recombination.
(J:275089)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tdo2 Mutation: |
37 strains or lines available
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Original: |
J:275089 Lanz TV, et al., Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis. Sci Rep. 2017 Jan 24;7:41271 |
All: |
1 reference(s) |
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