Hk2^tm1Nhy
Targeted Allele Detail

Summary

• Symbol: Hk2^tm1Nhy
• Name: hexokinase 2; targeted mutation 1, Nissim Hay
• MGI ID: MGI:6303968
• Synonyms: Hk2^f, Hk2^flox
• Gene: Hk2 Location: Chr6:82702006-82751435 bp, - strand Genetic Position: Chr6, 35.94 cM
• Alliance: Hk2^tm1Nhy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202526
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• LoxP sites were inserted into the introns flanking exons 4-10. (J:202526)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hk2 Mutation: 61 strains or lines available

References

• Original: J:202526 Patra KC, et al., Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. Cancer Cell. 2013 Aug 12;24(2):213-28
• All: 10 reference(s)