Cish^tm1Rest
Targeted Allele Detail

Summary

• Symbol: Cish^tm1Rest
• Name: cytokine inducible SH2-containing protein; targeted mutation 1, Nicholas Restifo
• MGI ID: MGI:6303640
• Gene: Cish Location: Chr9:107173858-107179983 bp, + strand Genetic Position: Chr9, 57.99 cM
• Alliance: Cish^tm1Rest page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228505
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 1 was replaced by a neomycin selection cassette. (J:228505)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cish Mutation: 24 strains or lines available

References

• Original: J:228505 Palmer DC, et al., Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance. J Exp Med. 2015 Nov 16;212(12):2095-113
• All: 7 reference(s)