Parp2^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Parp2^tm1.1Ics
• Name: poly (ADP-ribose) polymerase family, member 2; targeted mutation 1.1, Institut Clinique de la Souris
• MGI ID: MGI:6303586
• Synonyms: Parp-2^flox
• Gene: Parp2 Location: Chr14:51045347-51058758 bp, + strand Genetic Position: Chr14, 26.25 cM, cytoband C1
• Alliance: Parp2^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274546
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exon 8. An frt-flanked neomycin selection cassette in intron 8 was removed via FLP-mediated recombination. (J:274546)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Parp2 Mutation: 29 strains or lines available

References

• Original: J:274546 Navarro J, et al., PARP-1/PARP-2 double deficiency in mouse T cells results in faulty immune responses and T lymphomas. Sci Rep. 2017 Feb 9;7:41962
• All: 6 reference(s)