Bex2^tm1Kami
Targeted Allele Detail

Summary

• Symbol: Bex2^tm1Kami
• Name: brain expressed X-linked 2; targeted mutation 1, Akihide Kamiya
• MGI ID: MGI:6302823
• Synonyms: Bex2^EGFP
• Gene: Bex2 Location: ChrX:134967314-134968985 bp, - strand Genetic Position: ChrX, 57.37 cM
• Alliance: Bex2^tm1Kami page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274541
• Parent Cell Line: EGR-101 (ES Cell)
• Strain of Origin: C57BL/6NSlc

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 3 including the entire ORF was replaced with an in-frame EGFP coding sequence, followed by a loxP flanked neomycin selection cassette. RT-PCR analysis confirmed the absence of mRNA transcripts in the targeted ES cells and loss of mRNA expression in the brain and testis of hemizygous male mice. (J:274541)

Expression

In Mice Carrying this Mutation:

62 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bex2 Mutation: 4 strains or lines available

References

• Original: J:274541 Ito K, et al., Gene targeting study reveals unexpected expression of brain-expressed X-linked 2 in endocrine and tissue stem/progenitor cells in mice. J Biol Chem. 2014 Oct 24;289(43):29892-911
• All: 2 reference(s)