Oip5os1^em1Dpbl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Oip5os1^em1Dpbl
• Name: Opa interacting protein 5, opposite strand 1; endonuclease-mediated mutation 1, David P Bartel
• MGI ID: MGI:6295975
• Synonyms: Cyrano^M1
• Gene: Oip5os1 Location: Chr2:119424777-119431227 bp, + strand Genetic Position: Chr2, 59.97 cM
• Alliance: Oip5os1^em1Dpbl page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Intragenic deletion
• Mutation details: CRISPR targeting of the site for induction of Mir 7 degradation within exon 3 resulted in a 2 bp deletion in the extended seed region, reducing the size of the internal loop. This mutation abolishes the ability to promote Mir7 destruction. (J:265657)

Expression

In Mice Carrying this Mutation:

10 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oip5os1 Mutation: 6 strains or lines available

References

• Original: J:265657 Kleaveland B, et al., A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain. Cell. 2018 Jul 12;174(2):350-362.e17
• All: 1 reference(s)