Mirc23^tm1.1Shbk
Targeted Allele Detail

Summary

• Symbol: Mirc23^tm1.1Shbk
• Name: microRNA cluster 23, including Mir374b through Mir421; targeted mutation 1.1, Shin Kobayashi
• MGI ID: MGI:6287756
• Synonyms: miRNA374/421 DKO
• Gene: Mirc23 Location: unknown Genetic Position: ChrX, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268562
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mirc23^tm1.1Shbk involves 3 genes/genome features (Mir421, Mir374b, Mir374c) View all
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of Mir374b. An additional loxP site was inserted downstream of Mir421. Cre-mediated mutation removed the selection cassette and the microRNAs. (J:268562)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc23 Mutation: 1 strain or line available

References

• Original: J:268562 Hosoi Y, et al., Female mice lacking Ftx lncRNA exhibit impaired X-chromosome inactivation and a microphthalmia-like phenotype. Nat Commun. 2018 Sep 20;9(1):3829
• All: 1 reference(s)