Igh-V^tm1.2Rsky
Targeted Allele Detail

Summary

• Symbol: Igh-V^tm1.2Rsky
• Name: immunoglobulin heavy chain variable region; targeted mutation 1.2, Klaus Rajewsky
• MGI ID: MGI:6287289
• Synonyms: B1-8VH12^fli
• Gene: Igh-V Location: unknown Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271722
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The targeting construct introduced floxed segment containing an inverted VH12 and Igh-driven B1-8. Cre-mediated recombination removed the neomycin resistance cassette and flips the expression cassettes such that VH12 is expressed. (J:271722)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh-V Mutation: 5 strains or lines available

References

• Original: J:271722 Graf R, et al., BCR-dependent lineage plasticity in mature B cells. Science. 2019 Feb 15;363(6428):748-753
• All: 1 reference(s)