Lepr^m9Btlr
Chemically induced Allele Detail

Summary

• Symbol: Lepr^m9Btlr
• Name: leptin receptor; mutation 9, Bruce Beutler
• MGI ID: MGI:6286253
• Synonyms: gordo
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^m9Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to A transversion at base pair 101,765,305 (v38) on chromosome 4, or base pair 48,018 in the GenBank genomic region NC_000070. The mutation corresponds to residue 1,832 in the mRNA sequence NM_146146 within exon 9 of 19 total exons. The mutation results in an aspartic acid to glutamic acid substitution at position 427 (D427E) in the LEPR protein. (J:272857)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 121 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=4005

References

• Original: J:272857 Zhang Z, et al., Mutagenetix entry for gordo. MGI Direct Data Submission. 2019
• All: 1 reference(s)