Pappa2^M4Btlr
Chemically induced Allele Detail

Summary

• Symbol: Pappa2^M4Btlr
• Name: pappalysin 2; mutation 4, Bruce Beutler
• MGI ID: MGI:6283598
• Synonyms: Pitzel
• Gene: Pappa2 Location: Chr1:158539297-158788019 bp, - strand Genetic Position: Chr1, 68.49 cM
• Alliance: Pappa2^M4Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to T transversion at base pair 158,956,645 (v38) on chromosome 1, or base pair 23,883 in the GenBank genomic region NC_000067. The mutation corresponds to residue 794 in the mRNA sequence NM_001085376 within exon 1 of 22 total exons. The mutation results in a tyrosine to phenylalanine substitution at position 265 (Y265F) in the PAPP-A2 protein. (J:271978)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pappa2 Mutation: 87 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3640

References

• Original: J:271978 Zhang Z, et al., Mutagenetix entry for Pitzel. MGI Direct Data Submission. 2019
• All: 1 reference(s)