Lrit2^em1Tfur
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lrit2^em1Tfur
• Name: leucine-rich repeat, immunoglobulin-like and transmembrane domains 2; endonuclease-mediated mutation 1, Takahisa Furukawa
• MGI ID: MGI:6281025
• Gene: Lrit2 Location: Chr14:36789886-36795700 bp, + strand Genetic Position: Chr14, 21.29 cM
• Alliance: Lrit2^em1Tfur page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology generated a 1 bp insertion in exon 2 that results in a frame shift and a premature stop codon after the 51st amino acid residue of the N-terminal domain. (J:271244)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrit2 Mutation: 34 strains or lines available

References

• Original: J:271244 Ueno A, et al., Lrit1, a Retinal Transmembrane Protein, Regulates Selective Synapse Formation in Cone Photoreceptor Cells and Visual Acuity. Cell Rep. 2018 Mar 27;22(13):3548-3561
• All: 1 reference(s)