Gdpd3^em1Tsr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gdpd3^em1Tsr
• Name: glycerophosphodiester phosphodiesterase domain containing 3; endonuclease-mediated mutation 1,Theodora S Ross
• MGI ID: MGI:6280493
• Synonyms: Gdpd3^-
• Gene: Gdpd3 Location: Chr7:126365586-126374817 bp, + strand Genetic Position: Chr7, 69.25 cM, cytoband F4
• Alliance: Gdpd3^em1Tsr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 endonuclease-mediated NHEJ genome editing is used to delete exons 2 through 7 resulting in a frameshift mutation and introducing a premature stop codon in exon 7. qPCR analysis confirmed the absence of mRNA expression in liver, lung, and spleen tissue of homozygous mutant mice. (J:267987)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gdpd3 Mutation: 14 strains or lines available

References

• Original: J:267987 Wijayatunge R, et al., Deficiency of the Endocytic Protein Hip1 Leads to Decreased Gdpd3 Expression, Low Phosphocholine, and Kypholordosis. Mol Cell Biol. 2018 Dec 1;38(23)
• All: 1 reference(s)