Hip1^{tm5.1(HIP1)Tsr}
Targeted Allele Detail

Summary

• Symbol: Hip1^{tm5.1(HIP1)Tsr}
• Name: huntingtin interacting protein 1; targeted mutation 5.1, Theodora S Ross
• MGI ID: MGI:6280488
• Synonyms: Hip1^LSL
• Gene: Hip1 Location: Chr5:135435385-135573974 bp, - strand Genetic Position: Chr5, 75.18 cM, cytoband F-G2
• Alliance: Hip1^{tm5.1(HIP1)Tsr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267987
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector contains a floxed STOP cassette (LSL) inserted into intron 1, followed by a partial exon 2 fused to a human HIP1 (huntingtin interacting protein 1) cDNA, IRES-EGFP, and a polyadenylation signal sequence. An FRT-flanked neomycin cassette inserted after the poly(A) was removed by a Flp-expressing plasmid. Western blot analysis on lung tissue confirmed the absence of mouse Hip1 protein. (J:267987)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hip1 Mutation: 67 strains or lines available

References

• Original: J:267987 Wijayatunge R, et al., Deficiency of the Endocytic Protein Hip1 Leads to Decreased Gdpd3 Expression, Low Phosphocholine, and Kypholordosis. Mol Cell Biol. 2018 Dec 1;38(23)
• All: 1 reference(s)