Timp2^{em1(IMPC)Hmgu}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Timp2^{em1(IMPC)Hmgu}
• Name: tissue inhibitor of metalloproteinase 2; endonuclease-mediated mutation 1, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:6276911
• Gene: Timp2 Location: Chr11:118191887-118246237 bp, - strand Genetic Position: Chr11, 83.09 cM
• Alliance: Timp2^{em1(IMPC)Hmgu} page
• IMPC: Timp2 gene page

Mutation origin

• Strain of Origin: C57BL/6N
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at Helmholtz-Zentrum Muenchen using Cas9 and guides with spacer sequences GAAACGGTTAACGAATGGCC, GATTTTGTTGGGTGATACAC, GTAAGCGGCCCAGCACAGGG, and GTTCGCAGCCACCCGGGCAG that targeted exon(s) ENSMUSE00001215436.2 ENSMUSE00001493616.1. This resulted in deletion(s) of 27 bp (location: Chr11:118210310-118210336; GRCm39), 1436 bp (location: Chr11:118210342-118211777; GRCm39). This description was generated automatically. Additional molecular information including FASTA sequence support for this allele can be found here: (IMPC Gene page) and viewed in a genome context here: (IMPC Genome Browser). (J:384794)

• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Timp2 Mutation: 21 strains or lines available

References

• Original: J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023
• All: 4 reference(s)