Agt^tm2.1Ii
Targeted Allele Detail

Summary

• Symbol: Agt^tm2.1Ii
• Name: angiotensinogen; targeted mutation 2.1, Iekuni Ichikawa
• MGI ID: MGI:6201435
• Synonyms: Agt^loxP
• Gene: Agt Location: Chr8:125283326-125296445 bp, - strand Genetic Position: Chr8, 72.81 cM
• Alliance: Agt^tm2.1Ii page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264459
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: One loxP into upstream of exon 2, loxP flanked neo cassette into intron 2 were inserted via homologous recombination. Transient expression of cre in ES cells removed neo cassette leaving exon 2 flanked by loxP. (J:264459)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agt Mutation: 34 strains or lines available

References

• Original: J:264459 Matsusaka T, et al., Liver angiotensinogen is the primary source of renal angiotensin II. J Am Soc Nephrol. 2012 Jul;23(7):1181-9
• All: 2 reference(s)