Bpifa1^tm1.2Jpst
Targeted Allele Detail

Summary

• Symbol: Bpifa1^tm1.2Jpst
• Name: BPI fold containing family A, member 1; targeted mutation 1.2, James P Stewart
• MGI ID: MGI:6200800
• Synonyms: Bpifa1^-
• Gene: Bpifa1 Location: Chr2:153984800-153991137 bp, + strand Genetic Position: Chr2, 76.15 cM
• Alliance: Bpifa1^tm1.2Jpst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265391
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted in to intron 1 and an FRT site, a loxP site, a neomycin resistance gene cassette, and a second FRT-loxP site pair into intron 3. The neo cassette was removed through subsequent flp-mediated recombination. Floxed exons 2 and 3 were deleted through subsequent cre-mediated recombination. (J:265391)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bpifa1 Mutation: 24 strains or lines available

References

• Original: J:265391 Akram KM, et al., An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection. Mucosal Immunol. 2018 Jan;11(1):71-81
• All: 2 reference(s)