Rag2^tm1.1Liux
Targeted Allele Detail

Summary

• Symbol: Rag2^tm1.1Liux
• Name: recombination activating gene 2; targeted mutation 1.1, Xiaolong Liu
• MGI ID: MGI:6189200
• Synonyms: RAG2-C478Y
• Gene: Rag2 Location: Chr2:101455063-101462874 bp, + strand Genetic Position: Chr2, 53.87 cM
• Alliance: Rag2^tm1.1Liux page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:246880
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The nucleotide substitution resulted in the amino acid substitution of tyrosine for cysteine at position 478 (C478Y). Cre-mediated recombination removed the floxed selection cassette. (J:246880)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rag2 Mutation: 115 strains or lines available

References

• Original: J:246880 Xu K, et al., Disruption of the RAG2 zinc finger motif impairs protein stability and causes immunodeficiency. Eur J Immunol. 2016 Apr;46(4):1011-9
• All: 1 reference(s)